Mannose - Wikipedia
D-Mannose is a naturally occurring sugar that's closely related to glucose D- mannose works may be its relationship to Tamm-Horsfall protein. D-Mannose is the 2-epimer of glucose and exists primarily as . urinary tract infections (UTI), the second most common reason for physician visits in .. Taste- structure correlation with alpha-D-mannose and beta-D-mannose. Learn more about D-Mannose uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain D-Mannose.
Cranberries and lower urinary tract infection prevention
D-mannose for UTIs A growing body of research suggests that D-mannose may have a part to play in treating active UTIs and preventing them from developing in the future. Research into D-mannose for treating UTIs in people is still very new. For example, a review article noted the lack of clinical studies evaluating whether D-mannose could prevent UTIs from recurring.
Since then, journals have published some small studies, and researchers are currently conducting larger, more rigorous studies. A study in the World Journal of Urology found that D-mannose may be effective in preventing people from getting further UTIs after they have recovered from one.
In the study, D-mannose was slightly more effective than the antibiotic Nitrofurantoin.
However, the study participants knew whether they were taking D-mannose or not. Coffee beans, fenugreek and guar gums are rich sources of galactomannans [ 17 ], but these plant polysaccharides are not degraded in the mammalian GI tract and, therefore, provide very little bio-available mannose for glycan synthesis.
Can D-Mannose Treat or Prevent UTIs?
These polysaccharides are partially digested by anaerobic bacteria in the colon [ 18 ]. Small amounts of bio-available mannose occur in glycoproteins. Various cell lines transport 6. Most studies of GLUT substrate specificity assess only transport of glucose and fructose, but very rarely mannose transport.
Several reports describe SGLT-like mannose transporters in the intestine and kidney, where they could deliver free mannose from the diet or recover it from the urine [ 21 ]. To date, there is no evidence for the physiological importance of these transporters.
Within the cell, mannose is phosphorylated by hexokinase HK to produce mannosephosphate ManPwhich serves as a common substrate for three competing enzymes. Another minor pathway utilizes mannose for synthesis of 2-ketodeoxy-D-glycero-D-galacto-nononic acid KDNa sialic-acid related molecule found in fish and mammals [ 22 ] fig.
The fate of ManP largely depends on the ratio of MPI to PMM2 within a cell [ 19 ] - higher ratio leads to greater catabolism, while lower ratio favors the glycosylation pathway. A lot of different D-mannose products are available.
When deciding on which to use, you should consider three things: For now, the doses that have been used in research are recommended: For preventing frequent UTIs: For treating an active UTI: D-mannose comes in capsules and powders.
The form you choose mainly depends on your preference. Keep in mind that many products provide milligram capsules. This means that you may need to take two to four capsules to get the desired dose. To use D-mannose powder, dissolve it in a glass of water, and then drink the mixture.