Journal of Molecular Cell Biology | Oxford Academic
Journal of Molecular Cell Biology (JMCB) is a new international journal alternative to the existing ones such as Molecular Cell, Developmental Cell, Manuscripts that meet the following criteria can be submitted through 'Fast & Green Track'. Upon acceptance, authors should provide the manuscript in JMCB's format. Library: Meet the Author. In our Meet the Author series, read about the people and stories behind the papers. Volume Volume Volume Volume Molecular and Cellular Endocrinology was established in to meet the demand for integrated Guide for Authors . in Wistar rats are modified by the developmental exposure to a glyphosate-based herbicide Discover why open access is on the rise in Elsevier's Biochemistry, Genetics and Molecular Biology journals.
Despite great progress made towards a better understanding of the molecular basis of diabetes, the available clinical counter-measures against insulin resistance, a defect that is central to obesity-linked type 2 diabetes, remain inadequate. Adiponectin, an abundant adipocyte-secreted factor with a wide-range of biological activities, improves insulin sensitivity in major insulin target tissues, modulates inflammatory responses, and plays a crucial role in the regulation of energy metabolism.
Invited Review The FGF21—adiponectin axis in controlling energy and vascular homeostasis Whole-body energy metabolism and cardiovascular homeostasis are tightly controlled processes that involve highly coordinated crosstalk among distal organs.
Molecular and Cellular Endocrinology
This is mainly achieved by a large number of hormones released from each organ. Among them, fibroblast growth factor 21 FGF21 and adiponectin have recently gained considerable attention, since both of them possess multiple profound protective effects against a myriad of cardio-metabolic disorders. Despite their distinct structures and production sites, these two hormones share striking functional similarity.
Original Article Adipocyte-derived microvesicles from obese mice induce M1 macrophage phenotype through secreted miR The pro-inflammatory profile of M1 macrophage accumulation in adipose tissue is a central event leading to the metabolic complications of obesity. However, the mechanisms by which M1 macrophages are enriched in adipose tissue during weight gain remain incompletely understood. Here, we investigated the effects of adipocyte-derived microvesicles ADM on modulating macrophage phenotype in mice and explored the involved molecular signalling pathways.
Letter to the Editor Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering Type 1 diabetes T1D is a lifelong chronic disease and a major health problem throughout the world.
This disease can be treated by either insulin injection or islet transplantation.
Islet transplantation is considered as a better treatment for T1D patients, because islets can produce and release insulin at the appropriate time, resulting in tight blood glucose control. The discipline of anatomy is divided into macroscopic and microscopic anatomy.
The history of anatomy is characterized by a progressive understanding of the functions of the organs and structures of the human body. Cell-Biology Cell biology is a branch of biology that studies cells physiological properties, their structure, the organelles they contain, interactions with their environment, their life cycle, division, death and cell function. This is done both on a microscopic and molecular level.
Cell biology research encompasses both the great diversity of single-celled organisms like bacteria and protozoa, as well as the many specialized cells in multicellular organisms such as humans, plants, and sponges. To know the components of cells and how cells work is fundamental to all biological sciences.
In animals most development occurs in embryonic life, but it is also found in regenerationasexual reproduction and metamorphosis, and in the growth and differentiation of stem cells in the adult organism.
In plants, development occurs in embryos, during vegetative reproductionand in the normal outgrowth of roots, shoots and flowers. Developmental Biology has also help to generate modern stem cell biology which promises a number of important practical benefits for human health.
In biological terms, human development entails growth from a one celled zygote to an adult human being. Fertilization occurs when the sperm cell successfully enters and fuses with an egg cell. The genetic material of the sperm and egg then combine to form a single cell called a zygote and the germinal stage of prenatal development commences.
Human embryology is the study of this development during the first eight weeks after fertilization.
The normal period of gestation is nine months or 38 weeks. Crynofacial Genetics Human genetics is the study of inheritance as it occurs in human beings. Human genetics encompasses a variety of overlapping fields including: Genes can be the common factor of the qualities of most human-inherited traits. Study of human genetics can be useful as it can answer questions about human nature, understand the diseases and development of effective disease treatment, and understand genetics of human life.
The antibody recognizes a unique molecule of the harmful agent, called an antigen, via the variable region. Using this binding mechanism, an antibody can tag a microbe or an infected cell for attack by other parts of the immune system or can neutralize its target directly.
Antibodies are secreted by cells of the adaptive immune system B cellsand more specifically, differentiated B cells called plasma cells. Antigen-Presenting Cells An antigen-presenting cell APC is a cell that displays foreign antigens complexed with major histocompatibility complexes MHCs on their surfaces.
General_Instructions | Journal of Molecular Cell Biology | Oxford Academic
This process is known as antigen presentation. T-cells may recognize these complexes using their T-cell receptors TCRs. These cells process antigens and present them to T-cells. Antigen-presenting cells come under two categories: In mammals, these come under three general categories, they are: EnteroEndocrine Cells Enteroendocrine cells are specialized endocrine cells of the gastrointestinal tract and pancreas.
Frontiers in Cell and Developmental Biology
Enteroendocrine cells of the intestine are the most numerous endocrine cells of the body. Enteroendocrine cells are located in the stomach, in the intestine and in the pancreas. Epithelial tissues line the cavities and surfaces of structures throughout the body. Many glands are made up of epithelial cells.