Geomatrix technology (Jago Pharma, Muttenz, Switzerland) can control release of one or more drugs from a tablet containing different drugs in different layers. Download/Embed scientific diagram | Geomatrix Technology: two-and three-layer systems. from publication: Development of Controlled Release Three-layered. Geomatrix is the smartest solution to grow your retail sales, available in 67 countries. We integrate best official data and technologies in a single platform.

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tehnology Enabling individualized therapy through nanotechnology. In this case, there is an initial immediate rapid release of drug, which is followed by a sustained constant drug release. The role of the burst effect. This bilayered system design may thus be valuable for future application in the successful treatment of hypertension.

Geomatrix: one or two layers oral drug delivery platform technology

Assemblage of novel release modules for the development of adaptable drug delivery systems. Theophylline and diltiazem hydrochloride were employed as model drugs.

Bimodal drug release may be advantageous in that the initial rapid release phase which is followed by a slow release phase is able to compensate for the slow absorption of drug from the stomach and small intestine. It was also found that the drug release characteristics depended on the stirring rate and hole size [ 45 ]. A study by Kim investigated drug release from uncoated compressed tablets that contained a single central hole. The results depicted that the modules did not completely alter the kinetics compared to flat geomatdix matrices having the same weight and composition.

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This review focuses feomatrix the geometric technology that had been developed to provide controlled release of drugs. This type of release could be useful for drugs that need a high plasma concentration geomatrid for therapeutic efficacy where zero-order drug release kinetics is not required.

Commonly, in bilayered systems, one layer contains a quantity of drug for conferring immediate release, while the second layer contains a quantity of drug for extended release.

The relatively low dosage of this drug facilitates the rather complex dosage form design. We help clients integrate technologies – including middleware technology, integration applications, and legacy interfaces – to solve complex business problems. A study by Siahi and co-workers investigated the development of triple-layered tablets for the delivery of verapamil hydrochloride in a controlled tcehnology.

Influence of shape factors on kinetics of drug release from matrix tablets I: Currently most drug delivery systems exhibit first-order drug release kinetics where the plasma level of the drug is extremely high after administration and then decreases exponentially. We believe in nurturing a customer-centric ethos. Comparative evaluation of various structures in polymer controlled drug delivery systems and the effect of their morphology and characteristics on drug release. Fassihi and co-workers also investigated zero-order delivery of alfuzolin hydrochloride via a gastroretentive system.

The core layer is essentially coated with polymeric barrier layers by compression. The role of gamma scintigraphy in oral drug delivery. Compressed mini-tablet as a biphasic delivery system. Evidence via computer simulations and implications for epilepsy therapy. Results showed that the tablet was capable of delivering the drug constantly over 24 hours and was not dependent on the agitation or release medium [ 93 ]. The technology designs tablets with the ability to co-release multiple drugs with different release rates.

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The weight and thickness of the barrier layers also had a pivotal role in drug release behavior [ 70 ]. Sustained delivery by leucine-modified chitosan spray-dried respirable powders.

Oral Drug Delivery Systems Comprising Altered Geometric Configurations for Controlled Drug Delivery

The tablets also proved to be feasible to manufacture on a larger scale. Adequate controlled plasma drug levels, reduced side effects as well as improved patient compliance are some of the benefits that these systems may offer. Geomatrix technology is a gekmatrix drug delivery technolofy in the form of a multi-layer tablet proposed for constant drug release and was developed at University of Pavia, Italy.

This technology further adds to the varied geometrical systems for flexible and simplified drug delivery. Fundamentals of Controlled-Release and Drug Administration.

Swelling and release mechanism study. Hydrophilic polymers were employed as drug core matrices due to their swelling ability [ 73 — 76 ].

Oral Drug Delivery Systems Comprising Altered Geometric Configurations for Controlled Drug Delivery

Geolock TM Technology is a triple layered tablet that has been devised for chronotherapy focused-real time oral drug delivery [ 85 ]. Controlled delivery systems that geoatrix provide zero-order drug delivery have the potential for maximizing efficacy while minimizing dose frequency and toxicity.

Plasma drug concentration versus time profile exhibiting the effect of zero-order drug release on plasma drug levels adapted from Shahiwala et al.