Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Diana Finzi, Joel N. Combination therapy for HIV-1 infection can reduce plasma virus to Thus, latent infection of resting CD4+ T cells provides a mechanism for lifelong persistence Diana Finzi, Joel Blankson, +14 authors Robert F. Siliciano; Published in. Due to the importance of the latent reservoir in maintaining infection despite .. the long-term persistence of latent virus in HIV-infected individuals Finzi et al.

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The mean half-life of the latent reservoir was very long Detection of mutations associated with zidovudine resistance in human immunodeficiency virus by use of polymerase chain reaction.

Phylogenic analysis by standard methods 29 — 31 revealed the expected clustering of sequences of distinct biological clones obtained from individual patients. This paper has highly influenced 26 other papers.

Drug-resistance mutations generated by previous nonsuppressive regimens persisted in this compartment despite more than 1 year of fully suppressive HAART, rendering untenable the idea of recycling drugs that were part of failed regimens. Lifespan of human lymphocyte subsets defined by CD45 isoforms. Women and Infants Transmission Study Group. Wong JK, et al. Deficient human immunodeficiency virus type 1-specific cytotoxic T cell responses in vertically infected children.

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HIV-1 entry into quiescent primary lymphocytes: Combination therapy for HIV-1 infection can reduce plasma virus to undetectable levels, indicating that prolonged treatment might eradicate the infection. If the latent reservoir consists of only 1 x cells, eradication could take as long as 60 years.

A stable latent reservoir for HIV-1 in resting CD4+ T lymphocytes in infected children

In vivo estimates of division and death rates of human T lymphocytes. Mathematical and statistical methods.

The contribution of monocyte infection and trafficking to viral persistence, and ifnection of the viral reservoir in HIV infection. Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy.

Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection.

Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. However, the data presented here indicate that the latent reservoir for HIV-1 is established in infected children and will likely represent a major barrier to virus eradication that will have to be considered in all therapeutic strategies for the treatment of pediatric HIV-1 infection.

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A rapid method for simultaneous detection of phenotypic resistance to inhibitors of protease and reverse transcriptase in recombinant human immunodeficiency virus type 1 isolates from patients treated with antiretroviral drugs. AB – Combination therapy for HIV-1 infection can reduce plasma virus to undetectable levels, indicating that prolonged treatment might eradicate the infection.

Blanks represent codons not determined. Los Alamos National Laboratory. In contrast, 5 of the 6 children who were treated previously with incompletely suppressive regimens of zidovudine and didanosine finxi who had suppression of viral oatent for 12—30 months on HAART had persistence of replication-competent HIV-1 harboring mutations conferring resistance to zidovudine and didanosine.

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Chun Lstent, et al. From This Paper Figures, tables, and topics from this paper. Chadwick3 Joseph B. In comparing the latent reservoir for HIV-1 in children and adults, the following conclusions can be drawn. HIV-1 dynamics in vivo: These results demonstrate persistence of latent HIV-1 near the limit of detection, with possible slow decay.

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Decay characteristics of HIVinfected compartments during combination therapy. Journal List J Clin Invest v. Nature Medicine5 5 Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapy.

Patient 8 was started on combination therapy with ritonavir 19 months before the first analysis. Zhang L, et al. The positions of the primers are numbered according to the pol gene of the HXB2R isolate http: Highly active antiretroviral therapy.