Fundamental principles of bhaishajya kalpana. The word Bhaishajya Kalpana is composed of two words – Bhaishajya and Kalpana. The word. Bhaishjya kalpana deals with the Basic Ayurvedic pharmaceutics. •The first systematic knowledge of Bhaishajya Kalpana is found in Caraka. Doctor of Medicine in Rasashastra & Bhaishajya Kalpana (Medicinal Chemistry and Pharmacy) is Non – Clinical course. Keeping with tradition, the course.
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This can be achieved through specific processing. In a study carried out by Sudhir Joshi – Yastimadhu Glycyrrhiza glabra Linn was administered in three formulation forms and subjected to comparative evaluation. During preparation the fine paste and liquids are mixed together and then oil or ghee is added and boiled on mild fire and continuously stirred to ensure that the fine paste does not stick to the vessel.
It is necessary that the form of the drugs or formulations when ready for ingestion, should be not only effective but also easy to administer and agreeable to patient.
The pharmaceutical procedures for any drug involve various steps starting from identification and collection of authentic raw material, application of standardized processing techniques, and production of quality drug to packaging and storage of the produced drug. In one of the studies carried out in our lab Savrikar, three samples of guduchi ghritas were prepared using cow ghee ghrita obtained from three different regions- Wardha, Nanded and Solapur and the samples were evaluated for different pharmacological activities.
Medicated oils when used for internal purpose are administered along with adjuvants known as anupana. The plants growing in a graveyard or on a footpath should also not be collected.
Bhaishajya Kalpanaa – The Ayurvedic Pharmaceutics – An Overview
Before use on the body part, the powder is mixed with some liquid or other medium indicated for each preparation and made into a soft paste. The leaves collected during November and July were almost inactive. It should not adhere together or become moist. These are shown in Table 2. It is obtained by boiling the finely powdered plant material in required quantity of water till all the active ingredients are extracted completely in the water. Administration of cyclophosphamide caused significant suppression in anti-body formation.
Each of the above dosage forms is a subject that would require writing an independent article to do justice. It is bgaishajya that because of the ecological conditions prevailing in different parts from where the material is procured the same material collected from different regions may not have same activity profile.
Bhaishajya Kalpanaa – The Ayurvedic Pharmaceutics – An Overview
Water, Cow’s urine, oil, and ghee are some of the media used for mixing. A vast scope exists for undertaking well planned multi-disciplinary studies in this field in which at most importance should be given to the concepts behind formulation. Abstract In Ayurvedic therapeutics, drug therapy is given prime importance.
Due to space constraint it is not possible to give full description of all these forms. Apart from oral dosage forms, drugs administered through other routes of administration such as per-rectal, per urethral, per vaginal, nasal etc. Kwaatha- the decoction It is obtained by boiling the finely powdered plant material in required quantity of water till all the active ingredients are extracted completely in the water.
Hence while making changes in the classical formulation this point should be noted and changes should not be made without valid reasons. Thesis submitted to Gujarat Ayurved University – Jamnagar.
Shri Ayurved Mahavidyalaya
They are purified by boiling the raw material with different liquid materials till a soft mass is obtained and repeatedly processed to obtain its purified form known as sodhita guggulu. The investigators tend to ignore this aspect. The reason for boiling the plant material in water is to extract the entire water soluble ingredients.
Influence of season and place of collection In one of the studies it has been shown that season of collection of raw drugs can influence the expression of pharmacological activity Sridhara Bairy, The authors of such works have categorized the drugs in different manners.
Formulation factors influencing expression of pharmacological activity Though it is generally accepted among the ayurvedic fraternity that drug formulation is very important for ensuring therapeutic efficacy, not much importance is being given to assess or ascertain the impact of changes made in formulation factors on the expression of pharmacological activity. Comparative Pharmaco-clinical study on Panchtikta ghrita prepared by different methods in Ekakustha Psoriasis M.
Water being universal solvent is used for majority of extractions. Significant decrease in ulcer index was observed in Yasti ghrita administered group; in other two groups only moderate and statistically non-significant decrease was observed. Ghana is a dried aqueous extract. The third part of the review is devoted to discussion of influence of different factors on the expression of pharmacological activity. Sometimes the plant parts may not be containing enough moisture to obtain the juice by applying mechanical pressure.
Pills containing minerals can be used for an indefinite period. Dissertation submitted to Gujarat Ayurved University, Jamnagar. Further, Ayurvedic classics also give emphasis to the elimination of inherent constituents of the drug which are inappropriate in specific clinical condition and toxic in nature and which enter into the formulation if not removed.
This process ensures absorption of the active therapeutic properties of the ingredients used, into the oil base.
The plant ingredients are dried and made into fine powders, separately and ground to soft pastes before they are rolled in to pills with the help of fingers. This clearly indicates that the ancient masters were aware of the existence of individual differences in the manifestation of disease and response to therapy.
This shows that source of adjuvant itself may influence the expression of pharmacological activity. The criterion to determine the final stage of the formulation before making pills is that it should not stick to the fingers when rolled. A detailed account of different stable dosage forms is given by the classics. This was taken care by devising appropriate dosage forms.