Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite?
Scientists try to figure out why exercise helps ward off cancer. A byproduct of exercise, lactic acid has been incorrectly accused of causing the. In the current paper, the relationship between cancer metabolism and cancer The accumulation of lactic acids in cancer cells promotes lactic acid transport by . Patients with cancer have many risk factors for developing lactic acidosis, including the cancer diagnosis itself. Patients No financial relationships relevant to.
For those being fed through an I. For those being fed through a PEG tube, either protocol can be used. For those with brain cancer or lung cancer I suggest the Cellect-Budwig protocol because maximum therapeutic doses of Cellect-Budwig can be achieved more quickly. These two protocols will now be discussed specifically related to cachexia patients.
The Cellect-Budwig Protocol Cellect, the main product in the Cellect-Budwig protocol, quickly changes the basic chemistry in the body. He suspects that these drugs block the absorption of minerals which in turn blocks the neuro transmissions to the brain.
The brain must have the minerals for transmission.
Lactate may be key for cancer development
Because of the lack of signals to the brain the body doesn't realize it needs to eat. Anoher issue with cachexia patients is that they may throw up their food, including their supplements. This is a very tough issue to address and only persistence and slowly but firmly building up to recommended doses may be able to allow the patient to reach their recommended doses. Doses of medications and antibiotics may be able to be reduced as the patient is able to build up to their recommended doses of natural products.
In other words, one way to address this issue would be to slowly start the person on the Cellect at a very minimal amount, as they will probably throw it back up. Then continue to be persistent working gently at this, until the person is able to consume larger amounts of the Cellect. Along the way they may be able to slowly get off of their pain medications.
The object is to get the minerals back into the body to get the neuro transmission to start taking place in the brain. This should allow the brain to start transmitting signals, telling them they are hungry. Coffee enemas also helps by removing the toxic waste from the body, resulting in great pain relief and many times the patient is able to reduce the pain medication or get off of it completely. Remember the medication in many instances is blocking the transmission of signal to the brain.
The coffee enema as well may interrupt the lactic acid cycle, as it will cause a release of toxins from the liver. Another very powerful way in addition to get minerals re-absorbed into the body would be through the use of a Cellect Retention Enema.
The product Cellect is used in place of the coffee. By placing Cellect into warm water and by giving the person a retention enema, this should allow for faster absorption of the minerals into the body and may prevent the patient from throwing up because the Cellect bypasses the stomach.
The patient should try to retain the enema for at least 15 minutes or more to allow for faster absorption of the minerals. They may have to build up as fast as they can and try and retain longer each time. The Cellect retention enema does not replace the coffee enema as they are used for two totally different issues.
However, further studies have since shown that mitochondrial defects only partially account for the phenomenon. Although certain malignancies indeed harbour mitochondrial defects that make aerobic glycolysis a necessity 15the majority of cancers are able to revert back to oxidative phosphorylation when lactic acid generation is inhibited Tumours commonly encounter fluctuating oxygen levels, periodically alternating between normoxic and hypoxic conditions This raises the distinct possibility that aerobic glycolysis has arisen as an adaptation to hypoxic conditions.
Use of oxygen-independent glycolysis would confer a proliferative advantage to cancer cells, making them less susceptible to hypoxic stress during episodes of spontaneous hypoxia 13even if that would come at a cost of energy inefficiency during times of adequate oxygenation.
This theory has been extended by suggesting cooperation between normoxic and hypoxic cancer cells within a tumour aimed at maximizing energy efficiency 2. It is proposed that the hypoxic cells are the primary utilizers of glucose, converting it via glycolysis to lactate. Furthermore, lactate secreted by the hypoxic cells would be taken up by normoxic cancer cells and then converted back to pyruvate for oxidation via the citric acid cycle 2 This theory, however, does not fully account for the preference of cancers for glycolysis under conditions of abundant oxygenation.
Components of glucose uptake and glycolytic pathways can be up-regulated by oncogenes such as Ras, Akt, and Myc 3. This observation is particularly intriguing, since oncogenic activation is often thought of as an early event in cancer development and progression, and aerobic glycolysis may hence actually predate the onset of hypoxic selection and have a functional role in the early stages of the disease. Other proposals have been put forward, primarily focusing on the mechanisms by which aerobic glycolysis could confer a proliferative advantage to cancer cells 313 As this pathway is much less efficient than oxidative phosphorylation in generating ATP, ie by approximately fold, the question is raised as to how a reduced supply of ATP can lead to improved proliferative potential.
One proposal states that the advantage of aerobic glycolysis lies in incomplete utilization of glucose, allowing upstream intermediates to be redirected for biosynthesis, thereby providing cancer cells with an abundance of building blocks for synthesis of essential cellular components such as macromolecules While such an explanation appears sound, there is still controversy regarding how common such a mechanism is in normal proliferating cells Another proposal states that acidification of the micro-environment by lactic acid, resulting from up-regulation of glycolysis, can be expected to lead to the development of acid-resistant phenotypes exhibiting a powerful, selective growth advantage that promotes unconstrained proliferation and tissue invasion of cancer cells These inflammatory mediators alter numerous metabolic processes, resulting in reduced muscle protein synthesis and increased muscle protein breakdown.
Inflammatory cytokines also stimulate the release of the adrenal hormone cortisol and neurotransmitter hormones called catecholamines; both cortisol and catecholamines can exacerbate catabolic wasting by disrupting muscle cell metabolism and altering the basal metabolic rate Siddiqui ; Morley Reductions in levels of testosterone and insulin-like growth factor-1 IGF-1 are thought to play an important role in catabolic wasting as well.
Both testosterone and IGF-1 exert anabolic actions in muscle tissue, so declining levels of these hormones can lead to reduced muscle mass Morley Be careful with glucose-rich intravenous feeding. This feeds the cancer more than it feeds you.
Also, please keep in mind that intravenous feeding, being invasive, offers a route for blood-borne infections. Before now, cachexia, characterized by muscle wasting and dramatic weight loss, was believed to spare the heart. But an Ohio State University study showed that the condition reduces heart function and changes the heart muscle structure in mice with colon cancer.
The study results support the idea that insufficient heart performance might also be responsible for fatigue symptoms, leading to less exercise and more severe muscle wasting. The study is published in an issue of the International Journal of Oncology.
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How to Stop Cachexia Recommendations from many cancer organizations encourage patients to eat whatever they want of the typical American diet; that is, more saturated fats, refined flours and sugars. But, all that does is feed the inflammation and fuel this muscle-wasting process and make the cachexia even worse!
Stopping or fixing cachexia is not a matter of simply eating more calories, from fats, carbs or protein. Rather, the disorder is a metabolic dysfunction driven by a chronic, low-grade pro-inflammatory condition with the unrelenting and consequent breakdown of muscle and other lean tissues.
Various biofactors have been identified as mediators of tissue wasting in cachexia. Additional factors include tumor-derived factors such as lipid mobilizing factor LMF and protein mobilizing factor PMFwhich can directly mobilize fatty acids and amino acids from adipose tissue and skeletal muscle respectively. And, in spite of the fatigue that many patients will experience, gentle resistance exercise is essential to maintain and rebuild fragile muscles.
A sound plant-based nutritional strategy will not only help curtail inflammation, but reduce free-radical damage, minimize platelet activation which can lead to dangerous blood clottingmanage blood sugar surges, and reduce serum levels of insulin-like growth factor 1 IGF-1which stimulates cell multiplication and inhibits cell death.
In addition, some studies have indicated that MSM and Vitamin C were able to reduce lactic acid; and, a substance called hydrazine sulfate was able to break the cachexia cycle.
Death to Cancer: Cancer and Lactic Acid Cycle
This was accomplished by the hydrazine sulfate being able to block a key enzyme in the liver to prevent lactic acid from getting converted back into glucose. Athletes and Lactic Acid Any athlete is familiar with lactic acid.
Athletes normally take pickle juice, D-Ribose, MSM methylsulfonylmethane and Vitamin C or other special things to get nutrients past the lactic acid blockade and thus get energy into the cells. Most cancer patients do not die from the cancer cells, rather they die from the damage to the non-cancerous cells. Thus, it is critical to get nutrients past the lactic acid blockage to nourish the non-cancerous cells immediately!!Ray Peat on lactic acid and cancer.
Every cancer patient who thinks they may have cachexia, no matter what protocol they are on, should start taking D-Ribose immediately. This combination is known to neutralize the lactic acid buildup after the workout and it stops the pain. Using the MSM and Vitamin C together, as they work synergistically, should have the same ability to neutralize the lactic acid in patients with cachexia as well. MSM and vitamin C can be purchased at the health food store.
Hydrazine Sulfate Hydrazine sulphate breaks this lactic acid cycle by blocking a key enzyme in the liver to prevent lactic acid from getting converted back into glucose.
Of all of the alternative treatments for cachexia, perhaps Hydrazine Sulfate is the best known. The reason is that it was designed specifically for cachexia. Hydrazine sulfate is the salt of hydrazine and sulfuric acid. Known by the trade name Sehydrin, it is a chemical compound that has been used as an alternative medical treatment for the loss of appetite anorexia and weight loss cachexia which is often associated with cancer.
Hydrazine sulfate has not been approved in the United States as safe and effective in treating any medical condition, although it is marketed as a dietary supplement. It is also sold over the Internet by websites that promote its use as a cancer therapy.